Pub. Date : 1997 May
PMID : 9150481
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice. | Taxoids | cystin 1 | Mus musculus |
| 2 | In this study, the ability of taxanes with differing abilities to promote spontaneous in vitro assembly of tubulin dimers into microtubules were tested for their ability to inhibit the progression of polycystic kidney disease in polycystic cpk/cpk mice. | Taxoids | cystin 1 | Mus musculus |
| 3 | We found that taxanes that are active in promoting microtubule assembly, including paclitaxel, 10-deactyl-taxol and cephalomannine increased the survival of polycystic cpk/cpk mice significantly longer than control animals. | Taxoids | cystin 1 | Mus musculus |
| 4 | We conclude that the ability to promote microtubule assembly may be necessary for paclitaxel and related taxanes to modulate the progression of polycystic kidney progression in cpk/cpk mice. | Taxoids | cystin 1 | Mus musculus |
| 5 | We conclude that the ability to promote microtubule assembly may be necessary for paclitaxel and related taxanes to modulate the progression of polycystic kidney progression in cpk/cpk mice. | Taxoids | cystin 1 | Mus musculus |