Title : Amplification of the DNA repair gene O6-methylguanine-DNA methyltransferase associated with resistance to alkylating drugs in a mammalian cell line.

Pub. Date : 1997 May 16

PMID : 9148943






1 Functional Relationships(s)
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1 Exposure of mouse 3T3 cells to increasing concentrations of CNU, and subsequent selection of resistant cells, led to the isolation of clones with 5-10 times higher levels of MGMT activity than in the control. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Mus musculus