Title : Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2.

Pub. Date : 1997 May

PMID : 9145919






2 Functional Relationships(s)
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1 In particular, (2S,4R)-4-methylglutamate and 4-methylene-glutamate were transported by EAAT1, with Km values of 54 microM and 391 microM, respectively, but potently blocked glutamate transport by EAAT2, with Kb values of 3.4 microM and 39 microM, respectively. 4-methylglutamic acid solute carrier family 1 member 2 L homeolog Xenopus laevis
2 Indeed, (2S,4R)-4-methylglutamate is the most potent blocker of EAAT2 yet described. 4-methylglutamic acid solute carrier family 1 member 2 L homeolog Xenopus laevis