Title : Inhibition of the constitutive activity of human 5-HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635.

Pub. Date : 1997 Mar

PMID : 9138675






2 Functional Relationships(s)
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1 Inhibition of the constitutive activity of human 5-HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635. Spiperone 5-hydroxytryptamine receptor 1A Homo sapiens
2 In contrast, spiperone inhibited basal [35S]-GTP gamma S binding by 30.2% (IC50 = 55.5 nM) in CHO-5-HT1A membranes but not in control untransfected membranes. Spiperone 5-hydroxytryptamine receptor 1A Homo sapiens