Pub. Date : 1997 Mar 28
PMID : 9129165
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Molecular modelling of CYP2E1 enzymes from rat, mouse and man: an explanation for species differences in butadiene metabolism and potential carcinogenicity, and rationalization of CYP2E substrate specificity. | 1,3-butadiene | cytochrome P450, family 2, subfamily e, polypeptide 1 | Rattus norvegicus |
| 2 | In particular, the activation of buta-1,3-diene can be explained by active site modelling with CYP2E1 enzymes sequenced from rat, mouse and man, where there is a non-conservative change T437H between rodent and human isozymes, together with a conservative change I438V between mouse and rat CYP2E1. | 1,3-butadiene | cytochrome P450, family 2, subfamily e, polypeptide 1 | Rattus norvegicus |
| 3 | In particular, the activation of buta-1,3-diene can be explained by active site modelling with CYP2E1 enzymes sequenced from rat, mouse and man, where there is a non-conservative change T437H between rodent and human isozymes, together with a conservative change I438V between mouse and rat CYP2E1. | 1,3-butadiene | cytochrome P450, family 2, subfamily e, polypeptide 1 | Rattus norvegicus |