Pub. Date : 1997 May
PMID : 9112409
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Testosterone (3 ng/ml) and its metabolites, estradiol (50 pg/ml) and dihydrotestosterone (DHT; 3 ng/ml), inhibited osmotically stimulated VP release in hypothalamo-neurohypophyseal system explants. | Estradiol | arginine vasopressin | Rattus norvegicus |
| 2 | The osmotically induced increase in VP mRNA content was also inhibited by testosterone and estradiol, but not by DHT. | Estradiol | arginine vasopressin | Rattus norvegicus |
| 3 | BSA conjugates of estradiol (200 nM) and DHT (10 mM) also inhibited osmotically stimulated VP release, and VP mRNA content was inhibited by BSA-estradiol, but not by BSA-DHT, suggesting nongenomic actions of the steroids. | Estradiol | arginine vasopressin | Rattus norvegicus |
| 4 | The differential effects of estradiol and DHT on VP mRNA imply distinct actions for these steroids, and the DHT mechanism uncouples regulation of VP release from VP mRNA content. | Estradiol | arginine vasopressin | Rattus norvegicus |