Title : Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione.

Pub. Date : 1997 Apr 25

PMID : 9111045






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Ceramide is a sphingolipid that is generated in the signaling of inflammatory cytokines such as tumor necrosis factor (TNF), which exerts many functional roles depending on the cell type where it is produced. Ceramides tumor necrosis factor-like Rattus norvegicus
2 Ceramide is a sphingolipid that is generated in the signaling of inflammatory cytokines such as tumor necrosis factor (TNF), which exerts many functional roles depending on the cell type where it is produced. Ceramides tumor necrosis factor-like Rattus norvegicus
3 Mitochondria isolated from TNF-treated cells showed an increase (2-3-fold) in the amount of ceramide compared with mitochondria from untreated cells. Ceramides tumor necrosis factor-like Rattus norvegicus
4 These results suggest that mitochondria are a target of ceramide produced in the signaling of TNF whose effect on mitochondrial electron transport chain leads to overproduction of hydrogen peroxide and consequently this phenomena may account for the generation of reactive oxygen species during TNF cytotoxicity. Ceramides tumor necrosis factor-like Rattus norvegicus
5 These results suggest that mitochondria are a target of ceramide produced in the signaling of TNF whose effect on mitochondrial electron transport chain leads to overproduction of hydrogen peroxide and consequently this phenomena may account for the generation of reactive oxygen species during TNF cytotoxicity. Ceramides tumor necrosis factor-like Rattus norvegicus