Pub. Date : 1997 Apr
PMID : 9084431
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The ICE-like protease inhibitor benzyloxycarbonyl-Val-Ala-Asp (O-methyl)fluoromethyl ketone (zVAD-fmk) was found to be extremely effective at preventing staurosporine-induced death of cerebellar granule neurones and yet was completely ineffective in preventing K+ deprivation-induced death. | benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | caspase 1 | Homo sapiens |
| 2 | Staurosporine induced cleavage of the 116-kDa poly (ADP-ribose) polymerase enzyme, a substrate of ICE-like proteases, to the 85-kDa product, and this cleavage was also blocked by zVAD. | benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | caspase 1 | Homo sapiens |