Title : Alpha 1-adrenoceptor activation of a non-selective cation current in rabbit portal vein by 1,2-diacyl-sn-glycerol.

Pub. Date : 1997 Mar 1

PMID : 9080371






3 Functional Relationships(s)
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1 The phospholipase C (PLC) inhibitor U73122 inhibited the amplitude of the noradrenaline-activated Icat in a concentration- and time-dependent manner and the IC50 was about 180 nM. Norepinephrine LOC100009319 Oryctolagus cuniculus
2 The phospholipase C (PLC) inhibitor U73122 inhibited the amplitude of the noradrenaline-activated Icat in a concentration- and time-dependent manner and the IC50 was about 180 nM. Norepinephrine LOC100009319 Oryctolagus cuniculus
3 It is concluded that noradrenaline activates Icat via a G-protein coupled to PLC and that the resulting DAG product plays a central role in the activation of cation channels via a protein kinase C-independent mechanism. Norepinephrine LOC100009319 Oryctolagus cuniculus