Title : Effect of cytochrome P450 2D1 inhibition on hydrocodone metabolism and its behavioral consequences in rats.

Pub. Date : 1997 Mar

PMID : 9067326






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In vivo, quinine (20 mg/kg) and budipine (10 mg/kg) produced a marked suppression in brain and plasma hydromorphone levels detected after the peripheral administration of hydrocodone, thus confirming that the doses used suppressed CYP2D1 activity. Quinine cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus