Pub. Date : 1997 Mar 15
PMID : 9067281
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We now report that LY231514 and its polyglutamates also markedly inhibit other key folate-requiring enzymes, including dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT). | Pemetrexed | dihydrofolate reductase | Homo sapiens |
| 2 | We now report that LY231514 and its polyglutamates also markedly inhibit other key folate-requiring enzymes, including dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT). | Pemetrexed | dihydrofolate reductase | Homo sapiens |
| 3 | For example, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibition against TS, DHFR, and GARFT, respectively. | Pemetrexed | dihydrofolate reductase | Homo sapiens |