Title : Different protein kinase C isozymes mediate lower esophageal sphincter tone and phasic contraction of esophageal circular smooth muscle.

Pub. Date : 1997 Mar

PMID : 9058601






2 Functional Relationships(s)
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1 In LES single cells isolated by enzymatic digestion and permeabilized by saponin, 1-2-dioctanoylglycerol-mediated contraction was inhibited by preincubation with PKC-betaII antiserum but not by other PKC antisera. 1,2-dioctanoylglycerol protein kinase C alpha Homo sapiens
2 N-Myristoylated peptides derived from the pseudosubstrate sequences of PKC isozymes were used to inhibit saponin, 1-2-dioctanoylglycerol-induced contraction of LES and ESO smooth muscle cells. 1,2-dioctanoylglycerol protein kinase C alpha Homo sapiens