Title : NADPH-initiated cytochrome P450-dependent free iron-independent microsomal lipid peroxidation: specific prevention by ascorbic acid.

Pub. Date : 1997 Jan

PMID : 9046019






1 Functional Relationships(s)
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1 It is proposed that the perferryl moiety P450 Fe3+.O2.- initiates lipid peroxidation by abstracting methylene hydrogen from polyunsaturated lipid to form lipid radical, which then combines with oxygen to produce the chain propagating peroxyl radical for subsequent formation of lipid peroxides. Hydrogen cytochrome P450 family 2 subfamily B member 6 Homo sapiens