Title : Human intestinal folate transport: cloning, expression, and distribution of complementary RNA.

Pub. Date : 1997 Mar

PMID : 9041240






1 Functional Relationships(s)
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1 Xenopus oocytes injected with hIFC-1 cRNA show induced folate uptake that was (1) saturable with substrate concentration (apparent Michaelis constant = 0.71 +/- 0.06 micromol/L; maximum velocity = 128 +/- 3 fmol x h(-1) x oocyte(-1)), (2) inhibited by methotrexate, folinic acid, and folic acid (Ki = 0.84 micromol/L, 0.71 micromol/L, and 10 micromol/L, respectively), and (3) sensitive to 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (Ki = 0.29 mmol/L). Leucovorin solute carrier family 19 member 1 Homo sapiens