Title : Transcriptional and post-transcriptional regulation of LDL receptor gene expression in PMA-treated THP-1 cells by LDL-containing immune complexes.

Pub. Date : 1997 Jan

PMID : 9034205






1 Functional Relationships(s)
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1 To determine whether the increase in transcriptional activity of the LDL-R gene was secondary to changes in the cholesterol regulatory pool we performed experiments in which the cell cholesterol content was modified by the addition of either 25-hydroxycholesterol and mevalonate or inhibitors of ACAT activity (SA-58035 and progesterone). 25-hydroxycholesterol low density lipoprotein receptor Homo sapiens