Title : Energy metabolism during apoptosis. Bcl-2 promotes survival in hematopoietic cells induced to apoptose by growth factor withdrawal by stabilizing a form of metabolic arrest.

Pub. Date : 1997 Feb 21

PMID : 9030519






3 Functional Relationships(s)
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1 Depletion of intracellular ATP by uncoupling the mitochondrial ATPase with 2,4-dinitrophenol or carbonyl cyanide p-trifluoromethoxyphenylhydrazone induced apoptosis in Bo cells with or without IL-3, but not in B14 or B15 cells. Adenosine Triphosphate interleukin 3 Homo sapiens
2 We conclude that IL-3 withdrawal leads to arrest of energy metabolism in which ATP levels are maintained. Adenosine Triphosphate interleukin 3 Homo sapiens
3 ATP depletion is a strong apoptotic signal which overrides IL-3 signaling in normal cells but is ineffective in bcl-2-overexpressing cells. Adenosine Triphosphate interleukin 3 Homo sapiens