Title : Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in HepG2 cells.

Pub. Date : 1997 Feb

PMID : 9027727






2 Functional Relationships(s)
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1 Cobalt and desferrioxamine, like hypoxia, stimulate the production of erythropoietin in HepG2 cells. Cobalt erythropoietin Homo sapiens
2 Incubation with cobalt or with desferrioxamine, however, leads to a decrease of the intracellular H2O2 level as revealed by the dihydrorhodamine 123 technique, perhaps causing the well-known enhanced erythropoietin production. Cobalt erythropoietin Homo sapiens