Title : The effects of cyclosporin A, dexamethasone and other immunomodulatory drugs on induced expression of IL-3, IL-4 and IL-8 mRNA in a human mast cell line.

Pub. Date : 1997 Jan 15

PMID : 9020523






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1 The effects of cyclosporin A, dexamethasone and other immunomodulatory drugs on induced expression of IL-3, IL-4 and IL-8 mRNA in a human mast cell line. Cyclosporine interleukin 3 Homo sapiens
2 Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4. Cyclosporine interleukin 3 Homo sapiens
3 Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4. Cyclosporine interleukin 3 Homo sapiens
4 At both concentrations of CsA, expression of IL-3 was inhibited to a greater extent than that of the other two cytokines. Cyclosporine interleukin 3 Homo sapiens
5 In conclusion, this study shows that cytokine expression, particularly of IL-3, is inhibited in a human mast cell line by CsA and DEX. Cyclosporine interleukin 3 Homo sapiens