Title : Prevention of cytokine-induced changes in leukocyte adhesion receptors by nonsteroidal antiinflammatory drugs from the oxicam family.

Pub. Date : 1997 Jan

PMID : 9008610






3 Functional Relationships(s)
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1 Piroxicam also decreased the release of gelatinase and lysozyme induced by TNF alpha, but not by PMA. Piroxicam tumor necrosis factor Homo sapiens
2 Interestingly, piroxicam prevented the conformational changes that beta 2 integrins underwent upon activation of neutrophils: the appearance of the activation epitope of CD11b, detected by the CBRM1/5 MAb, was blocked by piroxicam in TNF alpha-treated neutrophils. Piroxicam tumor necrosis factor Homo sapiens
3 Interestingly, piroxicam prevented the conformational changes that beta 2 integrins underwent upon activation of neutrophils: the appearance of the activation epitope of CD11b, detected by the CBRM1/5 MAb, was blocked by piroxicam in TNF alpha-treated neutrophils. Piroxicam tumor necrosis factor Homo sapiens