Title : Role of stearoyl-CoA desaturase in the modification of acyl composition of hepatic phosphatidylcholine by peroxisome proliferators.

Pub. Date : 1996 Dec

PMID : 8996638






5 Functional Relationships(s)
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1 The relative contribution of stearoyl-CoA desaturase and 1-acylglycerophosphocholine (1-acyl-GPC) acyltransferase, which are induced by peroxisome proliferators, to the increase in the proportion of oleic acid in C-2 position of phosphatidylcholine (PtdCho) in the liver of rats was investigated. Oleic Acid stearoyl-CoA desaturase Rattus norvegicus
2 With administration of these peroxisome proliferators, the proportion of oleic acid in C-2 position of PtdCho in hepatic microsomes was increased in commensurate with the increase in activities of stearoyl-CoA desaturase and 1-acyl-GPC acyltransferase. Oleic Acid stearoyl-CoA desaturase Rattus norvegicus
3 Multiple regression analysis revealed that although there is a high correlation among the three parameters examined, the partial correlation between the proportion of oleic acid in the C-2 position and the activity of stearoyl-CoA desaturase is significantly higher than that between the proportion of oleic acid in the C-2 position and the activity of 1-acyl-GPC acyltransferase. Oleic Acid stearoyl-CoA desaturase Rattus norvegicus
4 Multiple regression analysis revealed that although there is a high correlation among the three parameters examined, the partial correlation between the proportion of oleic acid in the C-2 position and the activity of stearoyl-CoA desaturase is significantly higher than that between the proportion of oleic acid in the C-2 position and the activity of 1-acyl-GPC acyltransferase. Oleic Acid stearoyl-CoA desaturase Rattus norvegicus
5 The contribution of stearoyl-CoA desaturase to the increase in the proportion of oleic acid in the C-2 position thus appears greater than that of 1-acyl-GPC acyltransferase. Oleic Acid stearoyl-CoA desaturase Rattus norvegicus