Title : Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation.

Pub. Date : 1996 Dec

PMID : 8986721






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Overexpression of catalytically inactive SHP-1 (acting as a dominant negative) restores the tyrosine phosphorylation of these signaling events and reverses KIR-mediated inhibition of NK cell cytotoxic function. Tyrosine protein tyrosine phosphatase non-receptor type 6 Homo sapiens