Title : A novel regulation of expression of the alpha-subunit of the G stimulatory protein by dopamine via D1 dopamine receptors.

Pub. Date : 1997 Jan

PMID : 8978725






2 Functional Relationships(s)
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1 The loss in Gs alpha was accompanied by reduced (64.3 +/- 0.35% of control values) NaF-mediated stimulation of adenylyl cyclase and was independent of accumulated cyclic AMP (cAMP) levels, because neither forskolin nor dibutyryl cAMP treatment of cells mimicked the DA-induced effects. Colforsin GNAS complex locus Homo sapiens
2 Gs alpha mRNA levels were also attenuated (52 +/- 3.5% of control values) by the D1-selective agonist SKF R-38393 but not by forskolin or dibutyryl cAMP. Colforsin GNAS complex locus Homo sapiens