Pub. Date : 1996 Apr
PMID : 8967374
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PGE2 and PGI2 inhibit ET-1 secretion from endothelial cells by stimulating particulate guanylate cyclase. | Dinoprostone | guanylate cyclase | Bos taurus |
| 2 | PGE2 and PGI2 each caused a three- to fourfold increase in both membrane and whole bovine aortic endothelial cell guanylate cyclase activity. | Dinoprostone | guanylate cyclase | Bos taurus |
| 3 | We conclude that PGE2 and PGI2 are likely to inhibit ET-1 secretion through the activation of the particulate guanylate cyclase, identifying a novel mechanism by which the prostanoids signal in the endothelial cell. | Dinoprostone | guanylate cyclase | Bos taurus |