Title : Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation.

Pub. Date : 1997 Jan 10

PMID : 8960070






1 Functional Relationships(s)
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1 The production rate of the main metabolites of colchicine"s 3-demethylcolchicine (3DMC) and 2-demethylcolchicine (2DMC), was linear in relation to incubation time, cytochrome (P450) content, and substrate concentration. 2-Demethylcolchicine cytochrome P450 family 2 subfamily B member 6 Homo sapiens