Title : Propofol and flurazepam act synergistically to potentiate GABAA receptor activation in human recombinant receptors.

Pub. Date : 1996 Oct 24

PMID : 8957231






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Potentiation of GABA receptor-activated current by low (1-10 microM) concentrations of propofol together with flurazepam (0.25-0.5 microM) was significantly greater than predicted by an additive response. Flurazepam GABA type A receptor-associated protein Homo sapiens
2 Thus, flurazepam, in addition to facilitating GABA receptor activity on its own, also increases on its own, also increases the apparent affinity of the GABAA receptor complex to propofol, resulting in a greater than expected potentiation by the combination of propofol plus flurazepam. Flurazepam GABA type A receptor-associated protein Homo sapiens