Title : Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1.

Pub. Date : 1996 Dec 20

PMID : 8955087






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 rOCT1 induced highly active transport of a variety of cations, including the classical substrates for cation transport, such as N-1-methylnicotinamide, 1-methyl-4-phenylpyridinium (MPP), and tetraethylammonium (TEA), but also the physiologically important choline. Tetraethylammonium solute carrier family 22 member 1 Rattus norvegicus
2 rOCT1 induced highly active transport of a variety of cations, including the classical substrates for cation transport, such as N-1-methylnicotinamide, 1-methyl-4-phenylpyridinium (MPP), and tetraethylammonium (TEA), but also the physiologically important choline. Tetraethylammonium solute carrier family 22 member 1 Rattus norvegicus
3 In oocytes rOCT1 also mediated efflux of MPP, which could be trans-stimulated by MPP and TEA. Tetraethylammonium solute carrier family 22 member 1 Rattus norvegicus
4 In voltage-clamped oocytes, transport of TEA and choline via rOCT1 produced inwardly directed currents, which were independent of extracellular ion composition or pH. Tetraethylammonium solute carrier family 22 member 1 Rattus norvegicus