Title : Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.

Pub. Date : 1996 Nov 21

PMID : 8950976






1 Functional Relationships(s)
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1 Furthermore, a dominant-negative p53 mutant (introduced by retroviral transduction) rescued LacZ21 cells from senescence and generated colonies with extended lifespan in which beta-gal expression was totally abolished. beta-D-galactose tumor protein p53 Homo sapiens