Title : Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease.

Pub. Date : 1996 Dec 6

PMID : 8940132






1 Functional Relationships(s)
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1 Studies in cells treated with these apoptotic stimuli reveal that both fodrin and poly(ADP-ribose) polymerase proteolysis are inhibited by acetyl-Tyr-Val-Ala-Asp chloromethyl ketone and CrmA, specific inhibitors of ICE/Ced-3 proteases. N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone caspase 1 Homo sapiens