Title : Calcium/calmodulin-dependent protein kinase IIalpha mediates activation of mitogen-activated protein kinase and cytosolic phospholipase A2 in norepinephrine-induced arachidonic acid release in rabbit aortic smooth muscle cells.

Pub. Date : 1996 Nov 22

PMID : 8939965






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Activation of adrenergic receptors with NE in VSMC caused translocation of CaM kinase II, MAP kinase, and cPLA2 to the nuclear envelope only in the presence of extracellular Ca2+. vsmc cytosolic phospholipase A2 Oryctolagus cuniculus
2 Therefore, it appears that in rabbit VSMC, NE, by promoting extracellular Ca2+ influx, increases CaM kinase II activity, leading to activation of MAP kinase and cPLA2 and translocation to the nuclear envelope, resulting in release of AA from the nuclear envelope for prostacyclin synthesis. vsmc cytosolic phospholipase A2 Oryctolagus cuniculus