Title : Adrenomedullin augments inducible nitric oxide synthase expression in cytokine-stimulated cardiac myocytes.

Pub. Date : 1996 Nov 15

PMID : 8921801






4 Functional Relationships(s)
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1 Incubation of the cultures with interleukin-1 beta (10 ng/mL) for 24 hours caused a significant increase in nitrite accumulation. Nitrites interleukin 1 beta Homo sapiens
2 Adrenomedullin significantly augmented nitrite production by interleukin-1 beta-stimulated but not by unstimulated cardiac myocytes in a dose-dependent manner (10(-10) to 10(-6) mol/L). Nitrites interleukin 1 beta Homo sapiens
3 The adrenomedullin-induced nitrite production by interleukin-1 beta-stimulated cells was accompanied by increased inducible NO synthase mRNA and protein expression. Nitrites interleukin 1 beta Homo sapiens
4 In the presence of dibutyryl cAMP, the interleukin-1 beta-induced nitrite accumulation was increased further, but the stimulatory effect of adrenomedullin on nitrite production was abolished. Nitrites interleukin 1 beta Homo sapiens