Pub. Date : 1996 Dec 1
PMID : 8913880
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calcium-calmodulin plays a major role in bradykinin-induced arachidonic acid release by bovine aortic endothelial cells. | Arachidonic Acid | kininogen 1 | Bos taurus |
| 2 | We provided evidence that calcium-calmodulin plays a major role in bradykinin-induced arachidonic acid release by bovine aortic endothelial cells. | Arachidonic Acid | kininogen 1 | Bos taurus |
| 3 | In cells labeled for 16 hr with 3H-arachidonic acid, ionomycin and Ca2(+)-mobilizing hormones such as bradykinin, thrombin and platelet activating factor induced arachidonic acid release. | Arachidonic Acid | kininogen 1 | Bos taurus |
| 4 | Bradykinin induced the release of arachidonic acid in a dose-dependent manner (EC50 = 1.6 +/- 0.7 nM). | Arachidonic Acid | kininogen 1 | Bos taurus |
| 5 | In a Ca2(+)-free medium, bradykinin was still able to release arachidonic acid but with a lower efficiency. | Arachidonic Acid | kininogen 1 | Bos taurus |
| 6 | Quinacrine (300 microM), a blocker of PLA2, completely inhibited bradykinin-induced arachidonic acid release. | Arachidonic Acid | kininogen 1 | Bos taurus |
| 7 | The B2 bradykinin receptor antagonist HOE-140 completely inhibited bradykinin-induced arachidonic acid release. | Arachidonic Acid | kininogen 1 | Bos taurus |
| 8 | The phospholipase C inhibitor U-73122 (100 microM) decreased bradykinin-induced arachidonic acid release. | Arachidonic Acid | kininogen 1 | Bos taurus |
| 9 | The calmodulin inhibitor W-7 (50 microM) drastically reduced the bradykinin- and ionomycin-induced arachidonic acid release. | Arachidonic Acid | kininogen 1 | Bos taurus |
| 10 | Also, forskolin decreased bradykinin-induced arachidonic acid release. | Arachidonic Acid | kininogen 1 | Bos taurus |