Pub. Date : 1996 Mar 28
PMID : 8901021
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We investigated the effect of two neurosteroids, pregnenolone and dehydroepiandrosterone sulfate on lipopolysaccharide-induced tumor necrosis factor (TNF) production in vivo and in vitro. | Dehydroepiandrosterone Sulfate | tumor necrosis factor | Homo sapiens |
| 2 | We investigated the effect of two neurosteroids, pregnenolone and dehydroepiandrosterone sulfate on lipopolysaccharide-induced tumor necrosis factor (TNF) production in vivo and in vitro. | Dehydroepiandrosterone Sulfate | tumor necrosis factor | Homo sapiens |
| 3 | Dehydroepiandrosterone sulfate and pregnenolone (10(-6)-10(-4) M) inhibited TNF production in vitro by lipopolysaccharide-stimulated human peripheral blood mononuclear cells or by the human THP-1 cell line, suggesting that this action might also be relevant in humans. | Dehydroepiandrosterone Sulfate | tumor necrosis factor | Homo sapiens |
| 4 | (2) The inhibitory effect of dehydroepiandrosterone sulfate and pregnenolone on TNF production was not reversed by the glucocorticoid receptor antagonist, mifepristone (RU38486). | Dehydroepiandrosterone Sulfate | tumor necrosis factor | Homo sapiens |