Pub. Date : 1996 Aug 30
PMID : 8880741
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Zn2+ inhibited macroscopic currents induced by NMDA at both NR1/NR2B and NR1/NR2A receptors. | Zinc | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
| 2 | Zn2+ inhibited macroscopic currents induced by NMDA at both NR1/NR2B and NR1/NR2A receptors. | Zinc | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
| 3 | At NR1/NR2B receptors the Zn2+ concentration-inhibition curve was monophasic, with an apparent affinity for Zn2/ of 1.6 microM, and inhibition by Zn2+ was not voltage-dependent. | Zinc | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
| 4 | In contrast, the Zn2+ concentration-inhibition curve at NR1/NR2A receptors was biphasic, with high (Ki = 0.08 microM) and low (Ki = 30 microM) affinity components. | Zinc | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
| 5 | Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors. | Zinc | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
| 6 | Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors. | Zinc | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
| 7 | Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors. | Zinc | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
| 8 | Thus, Zn2+ is more potent in producing voltage-independent block at NR1/NR2A than at NR1/NR2B receptors, but the maximal effect of Zn2+ is smaller at NR1/NR2A than at NR1/NR2B receptors. | Zinc | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
| 9 | The low affinity component of Zn2+ inhibition at NR1/NR2A receptors was voltage-dependent and may represent an open-channel blocking effect of Zn2+. | Zinc | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
| 10 | The low affinity component of Zn2+ inhibition at NR1/NR2A receptors was voltage-dependent and may represent an open-channel blocking effect of Zn2+. | Zinc | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |