Title : The disposition of 14C-levamisole in the lactating cow.

Pub. Date : 1996 Aug

PMID : 8879150






5 Functional Relationships(s)
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1 14C-Labelled residues in milk were highest in samples collected from 0-12 h after dosing (1.55 ppm and 1.86 ppm of levamisole equivalents from oral and subcutaneously dosed animals, respectively) and declined to 0.06 ppm in milk collected from 36-48 h after dosing. Carbon-14 Weaning weight-maternal milk Bos taurus
2 14C-Labelled residues in milk were highest in samples collected from 0-12 h after dosing (1.55 ppm and 1.86 ppm of levamisole equivalents from oral and subcutaneously dosed animals, respectively) and declined to 0.06 ppm in milk collected from 36-48 h after dosing. Carbon-14 Weaning weight-maternal milk Bos taurus
3 Milk collected from 0-48 h after dosing accounted for 0.2% (oral dose) and 0.6% (subcutaneous dose) of the total 14C-activity administered as 14C-levamisole. Carbon-14 Weaning weight-maternal milk Bos taurus
4 The parent compound, 14C-levamisole, accounted for 12% or less (declined with time after dosing) of the total 14C-activity in the milk. Carbon-14 Weaning weight-maternal milk Bos taurus
5 Three 14C-labelled metabolites (formed by oxidation of imidazoline ring and/or opening of thiazolidine ring) in the milk were isolated and identified. Carbon-14 Weaning weight-maternal milk Bos taurus