Title : GTP synthases. Proton pumping and phosphorylation in ligand-receptor-G alpha-protein complexes.

Pub. Date : 1996

PMID : 8865363






1 Functional Relationships(s)
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1 The cycle is driven by a ligand-mediated proton pump through the alpha-helices of the receptor, attachment of the conserved Tyr-Arg-Tyr receptor proton shuttle being made to an aspartate group on the Gs alpha-protein terminal sidechain, which is itself linked to the Asn-Gln interaction known to control movement and rotation of the alpha 2-helix between .GDP and .GTP structures. Guanosine Diphosphate GNAS complex locus Homo sapiens