Title : The effect of metformin on insulin receptors and lipid peroxidation in alloxan and streptozotocin induced diabetes.

Pub. Date : 1995

PMID : 8852272






1 Functional Relationships(s)
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1 In alloxan-induced diabetes metformin (Met) treatment led to an increase in insulin receptor number in liver plasma membranes (before Met: 46.50 +/- 2.69, after Met: 76.00 +/- 3.39 fmol/mg, p < 0.001) and a decrease in plasma lipid peroxidation levels compared to the non-treated group (before Met: 1.85 +/- 0.53, after Met: 1.10 +/- 0.09 nmol MDA/ml, p < 0.05). Metformin insulin receptor Rattus norvegicus