Title : 5,6-Dihydroxyindole-2-carboxylic acid, a diffusible melanin precursor, is a potent stimulator of lipopolysaccharide-induced production of nitric oxide by J774 macrophages.

Pub. Date : 1995 Nov 17

PMID : 8847957






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Pre-incubation of J774 murine macrophages with 5,6-dihydroxyindole-2-carboxylic acid (DHICA), a diffusible intermediate in the biosynthesis of eumelanins, leads to a marked increase in the levels of nitric oxide (NO) produced by lipopolysaccharide (LPS)-induced NO-synthase (iNOS). eumelanin nitric oxide synthase 2, inducible Mus musculus