Title : Two mitogenic regions of myelin basic protein interact with different receptors to induce Schwann cell proliferation in a cAMP dependent process.

Pub. Date : 1995 Dec 15

PMID : 8847737






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Two mitogenic regions of myelin basic protein interact with different receptors to induce Schwann cell proliferation in a cAMP dependent process. Cyclic AMP myelin basic protein Homo sapiens
2 Previous studies have shown that myelin basic protein (MBP) is mitogenic for Schwann cells (SCs) in the presence of elevated intracellular cAMP. Cyclic AMP myelin basic protein Homo sapiens
3 Previous studies have shown that myelin basic protein (MBP) is mitogenic for Schwann cells (SCs) in the presence of elevated intracellular cAMP. Cyclic AMP myelin basic protein Homo sapiens
4 Intracellular cAMP of SCs was transiently increased after the addition of macrophage conditioned medium, suggesting that macrophages may produce factors in vivo which can transiently elevate intracellular cAMP levels, allowing a wave of SC proliferation in response to MBP-related mitogens. Cyclic AMP myelin basic protein Homo sapiens
5 Intracellular cAMP of SCs was transiently increased after the addition of macrophage conditioned medium, suggesting that macrophages may produce factors in vivo which can transiently elevate intracellular cAMP levels, allowing a wave of SC proliferation in response to MBP-related mitogens. Cyclic AMP myelin basic protein Homo sapiens