Title : Thrombopoietin modulates platelet activation in vitro through protein-tyrosine phosphorylation.

Pub. Date : 1996 Jul

PMID : 8843545






12 Functional Relationships(s)
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1 Thrombopoietin modulates platelet activation in vitro through protein-tyrosine phosphorylation. Tyrosine thrombopoietin Homo sapiens
2 Although several proteins in platelets were tyrosine-phosphorylated by TPO treatment, TPO alone was unable to induce platelet aggregation. Tyrosine thrombopoietin Homo sapiens
3 TPO in conjunction with ADP augmented tyrosine phosphorylation of platelet proteins, including tyrosine-phosphorylated proteins induced by TPO alone. Tyrosine thrombopoietin Homo sapiens
4 TPO in conjunction with ADP augmented tyrosine phosphorylation of platelet proteins, including tyrosine-phosphorylated proteins induced by TPO alone. Tyrosine thrombopoietin Homo sapiens
5 TPO in conjunction with ADP augmented tyrosine phosphorylation of platelet proteins, including tyrosine-phosphorylated proteins induced by TPO alone. Tyrosine thrombopoietin Homo sapiens
6 Genistein inhibited protein-tyrosine phosphorylation in platelets induced by TPO with ADP and suppressed TPO-enhanced platelet aggregation. Tyrosine thrombopoietin Homo sapiens
7 Moreover, tyrosine phosphorylation of MAP-kinases induced by TPO alone and TPO with ADP was consistent with TPO-enhanced platelet aggregation. Tyrosine thrombopoietin Homo sapiens
8 Moreover, tyrosine phosphorylation of MAP-kinases induced by TPO alone and TPO with ADP was consistent with TPO-enhanced platelet aggregation. Tyrosine thrombopoietin Homo sapiens
9 Moreover, tyrosine phosphorylation of MAP-kinases induced by TPO alone and TPO with ADP was consistent with TPO-enhanced platelet aggregation. Tyrosine thrombopoietin Homo sapiens
10 These findings in the present study suggest that signal transduction involved in TPO-enhanced platelet aggregation is mediated in part by tyrosine-phosphorylated proteins, including MAP-kinases, in platelets through TPO-stimulated c-Mpl, TPO receptor. Tyrosine thrombopoietin Homo sapiens
11 These findings in the present study suggest that signal transduction involved in TPO-enhanced platelet aggregation is mediated in part by tyrosine-phosphorylated proteins, including MAP-kinases, in platelets through TPO-stimulated c-Mpl, TPO receptor. Tyrosine thrombopoietin Homo sapiens
12 These findings in the present study suggest that signal transduction involved in TPO-enhanced platelet aggregation is mediated in part by tyrosine-phosphorylated proteins, including MAP-kinases, in platelets through TPO-stimulated c-Mpl, TPO receptor. Tyrosine thrombopoietin Homo sapiens