Title : Suramin is a potent inhibitor of vascular endothelial growth factor. A contribution to the molecular basis of its antiangiogenic action.

Pub. Date : 1996 Jul

PMID : 8841939






9 Functional Relationships(s)
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Protein Name
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1 Suramin is a potent inhibitor of vascular endothelial growth factor. Suramin vascular endothelial growth factor A Homo sapiens
2 We have tested the hypothesis, whether the antiangiogenic effect of suramin may be mediated via inhibition of VEGF function. Suramin vascular endothelial growth factor A Homo sapiens
3 Using cultured endothelial cells and a [3H]thymidine incorporation assay we were able to show, that the action of VEGF upon mitogenicity is inhibited by suramin in a dose-dependent manner. Suramin vascular endothelial growth factor A Homo sapiens
4 Suramin inhibited VEGF-inducible tyrosine phosphorylation of KDR as determined by in vitro kinase assay. Suramin vascular endothelial growth factor A Homo sapiens
5 Moreover, suramin was shown to inhibit VEGF-induced tyrosine phosphorylation of KDR in intact cells, indicating an interaction of suramin with the VEGF-receptor KDR as the cause of its inhibitory activity. Suramin vascular endothelial growth factor A Homo sapiens
6 Moreover, suramin was shown to inhibit VEGF-induced tyrosine phosphorylation of KDR in intact cells, indicating an interaction of suramin with the VEGF-receptor KDR as the cause of its inhibitory activity. Suramin vascular endothelial growth factor A Homo sapiens
7 Moreover, suramin was shown to inhibit VEGF-induced tyrosine phosphorylation of KDR in intact cells, indicating an interaction of suramin with the VEGF-receptor KDR as the cause of its inhibitory activity. Suramin vascular endothelial growth factor A Homo sapiens
8 Moreover, suramin was shown to inhibit VEGF-induced tyrosine phosphorylation of KDR in intact cells, indicating an interaction of suramin with the VEGF-receptor KDR as the cause of its inhibitory activity. Suramin vascular endothelial growth factor A Homo sapiens
9 The antiangiogenic effect of suramin may be mediated-at least in part-by inhibition of VEGF function. Suramin vascular endothelial growth factor A Homo sapiens