Title : Simulation of human benzo[a]pyrene metabolism deduced from the analysis of individual kinetic steps in recombinant yeast.

Pub. Date : 1996 Mar

PMID : 8839044






4 Functional Relationships(s)
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1 Human cytochrome P450 1A1 (1A1) and microsomal epoxide hydrolase (mEH)-dependent metabolic activation of benzo[a]pyrene (BP) have been reconstituted with microsomes from yeast cells expressing the two enzymes. Benzo(a)pyrene epoxide hydrolase 1, microsomal Mus musculus
2 Human cytochrome P450 1A1 (1A1) and microsomal epoxide hydrolase (mEH)-dependent metabolic activation of benzo[a]pyrene (BP) have been reconstituted with microsomes from yeast cells expressing the two enzymes. Benzo(a)pyrene epoxide hydrolase 1, microsomal Mus musculus
3 A minimum kinetic model of BP metabolism by 1A1 and mEH was constructed on the basis of the overall kinetic parameters (Vmax, Km) for a number of individual steps determined with human 1A1 and mEH expressed in yeast. Benzo(a)pyrene epoxide hydrolase 1, microsomal Mus musculus
4 A minimum kinetic model of BP metabolism by 1A1 and mEH was constructed on the basis of the overall kinetic parameters (Vmax, Km) for a number of individual steps determined with human 1A1 and mEH expressed in yeast. Benzo(a)pyrene epoxide hydrolase 1, microsomal Mus musculus