Title : A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all three ligands.

Pub. Date : 1996 Oct 18

PMID : 8824238






1 Functional Relationships(s)
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1 Substitution of this whole predicted loop region with alanines completely abrogated high affinity binding of GM-CSF, IL-3, and IL-5. Alanine interleukin 3 Homo sapiens