Title : Alterations of thiamine phosphorylation and of thiamine-dependent enzymes in Alzheimer's disease.

Pub. Date : 1996 Mar

PMID : 8815392






1 Functional Relationships(s)
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1 Studies in autopsied brain tissue from neuropathologically proven AD patients reveal significantly reduced activities of the thiamine phosphate dephosphorylating enzymes thiamine diphosphatase (TDPase) and thiamine monophosphatase (TMPase) as well as the thiamine diphosphate-dependent enzymes, pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase (alpha KGDH) and transketolase. Thiamine Pyrophosphate acid phosphatase 3 Homo sapiens