Title : Nitric oxide inhibits LPS-induced tumor necrosis factor synthesis in vitro and in vivo.

Pub. Date : 1996

PMID : 8809229






1 Functional Relationships(s)
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1 The synthesis of TNF-alpha in J774 macrophages stimulated with LPS (0.1 microgram/ml) was increased in concentration-related fashion by NO synthase inhibitor L-NMMA (3-30-300 microM) and reduced by either L-arginine (3-30-300 microM) or the NO donor SIN-1 (1-10-100 microM). omega-N-Methylarginine tumor necrosis factor Homo sapiens