Title : Interleukin-1 beta-mediated glucose uptake by chondrocytes. Inhibition by cortisol.

Pub. Date : 1996 Jun

PMID : 8806115






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1 Interleukin-1 beta-mediated glucose uptake by chondrocytes. Glucose interleukin 1 beta Homo sapiens
2 The aim of this study was to investigate the in vitro effects of interleukin-1 beta (IL-1 beta) on cultured human articular chondrocytes from patients with osteoarthritis, by the evaluation of glucose uptake. Glucose interleukin 1 beta Homo sapiens
3 The aim of this study was to investigate the in vitro effects of interleukin-1 beta (IL-1 beta) on cultured human articular chondrocytes from patients with osteoarthritis, by the evaluation of glucose uptake. Glucose interleukin 1 beta Homo sapiens
4 We also investigated the inhibitory effect of cortisol on IL-1 beta-mediated glucose uptake. Glucose interleukin 1 beta Homo sapiens
5 Glucose uptake stimulation was observed 3 h after the addition of 100 pg/ml IL-1 beta (+70%) and increased up to 24 h (+145%). Glucose interleukin 1 beta Homo sapiens
6 Cortisol inhibited the action of IL-1 beta on glucose uptake because it reduced stimulating effects by 28% at concentrations as weak as 10(-6) mol/l. Glucose interleukin 1 beta Homo sapiens
7 The inhibition of IL-1 beta-mediated glucose uptake is suggested for studying the anti-IL-1 effect of other anti-rheumatic drugs. Glucose interleukin 1 beta Homo sapiens