Title : Insulin-like growth factor-I and IGF binding protein-3 remain high after GnRH analogue therapy in girls with central precocious puberty.

Pub. Date : 1996 Jul

PMID : 8796132






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 OBJECTIVE: IGF-I rises in normal adolescence and in central precocious puberty (CPP), secondary to a rise in sex steroids and GH. Steroids insulin like growth factor 1 Homo sapiens
2 CONCLUSIONS: The lack of suppression of both IGF-I and IGFBP-3, despite therapy which halts puberty and slows growth velocity, suggests that steroids may be involved in the induction of changes in the GH/IGF-I axis but not in their subsequent maintenance. Steroids insulin like growth factor 1 Homo sapiens