Pub. Date : 1996 Jun
PMID : 8793749
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EP receptor subtypes implicated in the PGE2-induced sensitization of polymodal receptors in response to bradykinin and heat. | Dinoprostone | kininogen 1 | Canis lupus familiaris |
| 2 | Our previous studies, in which we used in vitro canine testispermatic nerve preparations, showed that prostaglandin E2 (PGE2) augments both bradykinin (BK)- and heat-induced discharges of polymodal receptors. | Dinoprostone | kininogen 1 | Canis lupus familiaris |
| 3 | Our previous studies, in which we used in vitro canine testispermatic nerve preparations, showed that prostaglandin E2 (PGE2) augments both bradykinin (BK)- and heat-induced discharges of polymodal receptors. | Dinoprostone | kininogen 1 | Canis lupus familiaris |
| 4 | Our previous studies, in which we used in vitro canine testispermatic nerve preparations, showed that prostaglandin E2 (PGE2) augments both bradykinin (BK)- and heat-induced discharges of polymodal receptors. | Dinoprostone | kininogen 1 | Canis lupus familiaris |
| 5 | Our previous studies, in which we used in vitro canine testispermatic nerve preparations, showed that prostaglandin E2 (PGE2) augments both bradykinin (BK)- and heat-induced discharges of polymodal receptors. | Dinoprostone | kininogen 1 | Canis lupus familiaris |
| 6 | However, the PGE2 concentration required to augment the BK responses were 100 times lower than those necessary for the heat responses, suggesting that different receptors are involved in these phenomena. | Dinoprostone | kininogen 1 | Canis lupus familiaris |
| 7 | PGE2-induced augmentation of the BK responses was unaffected when treated with an antagonist for the EP1 receptor, AH6809. | Dinoprostone | kininogen 1 | Canis lupus familiaris |
| 8 | An agonist for the EP3 receptor, M&B28767, at > or = 10 nM, significantly augmented the BK responses in a concentration-dependent manner that mimics the PGE2-induced effect. | Dinoprostone | kininogen 1 | Canis lupus familiaris |
| 9 | These results indicate that the EP3 and EP2 receptor subtypes are differentially implicated in the respective PGE2-induced augmentation of BK responses and heat responses of polymodal receptors. | Dinoprostone | kininogen 1 | Canis lupus familiaris |