Title : Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production.

Pub. Date : 1996 Sep

PMID : 8784069






1 Functional Relationships(s)
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1 The cytokine combination of interleukin-1 beta (50 U/mL), tumor necrosis factor-alpha (10(3) U/mL), and interferon-gamma (10(3) U/mL) induced significant increases in MDA and nitrite and significant decreases in insulin and DNA in islets after 60-h incubation. Nitrites interleukin 1 beta Homo sapiens