Pub. Date : 1996 Aug
PMID : 8770006
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CFTR chloride channel activation by genistein: the role of serine/threonine protein phosphatases. | Genistein | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 2 | 37): C886-C893, 1995] that genistein, a tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in NIH/3T3 cells that have been stably transfected with an expression vector for the CFTR (NIH-CFTR cells). | Genistein | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 3 | 37): C886-C893, 1995] that genistein, a tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in NIH/3T3 cells that have been stably transfected with an expression vector for the CFTR (NIH-CFTR cells). | Genistein | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 4 | 37): C886-C893, 1995] that genistein, a tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in NIH/3T3 cells that have been stably transfected with an expression vector for the CFTR (NIH-CFTR cells). | Genistein | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 5 | 37): C886-C893, 1995] that genistein, a tyrosine kinase inhibitor, activates the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in NIH/3T3 cells that have been stably transfected with an expression vector for the CFTR (NIH-CFTR cells). | Genistein | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 6 | As measured by 125I efflux, genistein and calyculin A stimulate the CFTR to approximately 50% of the maximal activity with forskolin. | Genistein | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 7 | Neither agonist increases CFTR activity at saturating forskolin concentrations, but genistein and calyculin A have an additive effect on CFTR activity. | Genistein | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 8 | Proteolytic digestion of in vivo phosphorylated CFTR suggests that the CFTR is phosphorylated on the same sites during stimulation with genistein and forskolin but on different sites stimulation with calyculin A. | Genistein | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 9 | Proteolytic digestion of in vivo phosphorylated CFTR suggests that the CFTR is phosphorylated on the same sites during stimulation with genistein and forskolin but on different sites stimulation with calyculin A. | Genistein | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 10 | The data suggest that genistein and calyculin A inhibit different PPase activities, allowing CFTR phosphorylation and partial stimulation, by a basal PKA activity. | Genistein | cystic fibrosis transmembrane conductance regulator | Mus musculus |