Title : Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase.

Pub. Date : 1996 Aug 5

PMID : 8769129






3 Functional Relationships(s)
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1 Under equivalent conditions at 20 degrees C, pH 8.0, mammalian TR reduced lipoic acid by NADPH 15 times more efficiently than the corresponding NADH dependent reduction catalyzed by LipDH (297 min-1 for TR vs. 20.3 min-1 for LipDH). NAD dihydrolipoamide dehydrogenase Homo sapiens
2 In contrast, LipDH was only 0.048 times as efficient in the forward reaction as compared to the reverse reaction (using NADH and NAD+). NAD dihydrolipoamide dehydrogenase Homo sapiens
3 In contrast, LipDH was only 0.048 times as efficient in the forward reaction as compared to the reverse reaction (using NADH and NAD+). NAD dihydrolipoamide dehydrogenase Homo sapiens